FOG1/ZFPM1 was identified in a yeast two-hybrid screen for GATA-1 interacting proteins. GATA-1 is zinc finger transcription factor whose expression is restricted to hematopoietic cells and plays and essential role in erythroid development. FOG1/ZFPM1 is highly expressed in erythroid cells and megakaryocytes and appears to play both a GATA-1-dependent and -independent role in erythropoiesis and megakaryopoiesis. FOG1/ZFPM1 associates with GATA-1 as well as GATA-2 and GATA-3 as a heterodimer to activate or repress transcription.
Alternative names for
ZFPM1/FOG1 Antibody include friend of GATA protein 1 antibody, zinc finger protein ZFPM1 antibody, FOG-1 antibody, FOG antibody, ZNF408 antibody, ZNF89A antibody.