XPF/ERCC4 is suggested to play a role in the repair of DNA double-strand breaks (DSB), homologous recombination, and gene conversion via single-strand annealing (SSA). XPF/ERCC4 is an endonuclease that incises 5-prime DNA. Defects in XPF/ERCC4 cause xeroderma pigmentosum VI (XP6) an autosomal recessive disease characterized by hypersensitivity to sunlight and a predisposition to skin cancer as well as neurological abnormalities. Defects in XPF/ERCC4 are also responsible for XFE progeroid syndrome, a syndrome characterized by dwarfism, cachexia, and microcephaly.
Alternative names for
XPF/ERCC4 Antibody include ERCC4 antibody,
DNA repair endonuclease XPF antibody,
DNA excision repair protein ERCC-4 antibody,
DNA repair protein complementing XP-F cells antibody,
Xeroderma pigmentosum group F-complementing protein antibody,
excision repair cross-complementing rodent repair deficiency, complementation group 4 antibody,
xeroderma pigmentosum, complementation group F antibody,
xeroderma pigmentosum group F-complementing protein antibody,
excision-repair, complementing defective, in Chinese hamster antibody.