XPF/ERCC4 Antibody

XPF/ERCC4 is suggested to play a role in the repair of DNA double-strand breaks (DSB), homologous recombination, and gene conversion via single-strand annealing (SSA). XPF/ERCC4 is an endonuclease that incises 5-prime DNA. Defects in XPF/ERCC4 cause xeroderma pigmentosum VI (XP6) an autosomal recessive disease characterized by hypersensitivity to sunlight and a predisposition to skin cancer as well as neurological abnormalities. Defects in XPF/ERCC4 are also responsible for XFE progeroid syndrome, a syndrome characterized by dwarfism, cachexia, and microcephaly.

Alternative names for XPF/ERCC4 Antibody include DNA repair endonuclease XPF antibody, DNA excision repair protein ERCC-4 antibody, DNA-repair protein complementing XP-F cells antibody, xeroderma pigmentosum group F-complementing protein antibody, ERCC11 antibody, RAD1 antibody.