UPF3B Antibody

UPF3B (UPF regulator of nonsense transcripts homolog B) is involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. UPF3B recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2, UPF3B stimulates both ATPase and RNA helicase activities of UPF1 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9BZI7].

Alternative names for UPF3B Antibody include nonsense mRNA reducing factor 3B antibody, up-frameshift suppressor 3 homolog B antibody, up-frameshift suppressor 3 homolog on chromosome X antibody, hUpf3B antibody, hUpf3p-X antibody, RENT3B antibody, UPF3X antibody.