Topo II Alpha Antibody

Topoisomerases regulate topological states of DNA and are divided into type I and type II enzymes. Type II topoisomerases make double stranded breaks in DNA and allow the passage of another duplex DNA across the break to achieve unknotting of entangled DNA. Topo II Alpha is one of two described isoforms that are likely products of a gene duplication event. TopoII Alpha is also described to be involved in chromosome condensation, chromatid separation, and the relief of supercoil stress.

Alternative names for Topo II Alpha Antibody include DNA topoisomerase 2-alpha antibody, DNA topoisomerase II alpha isoenzyme antibody, TOP2A antibody, TOP2 antibody, TP2 antibody, TP2A antibody.