TopBP1 Antibody

Topoisomerases regulate topological states of DNA. DNA topoisomerase II-binding protein 1 (TopBP1) is a protein that interacts with the C-terminal region of topoisomerase II beta (Topo II beta). TopBP1 function has been found to be important to various aspects of cellular growth control such as DNA replication, the DNA damage checkpoint, and cell survival. TopBP1 interacts with several proteins through its BRCA1 C-terminal (BRCT) motifs. TopBP1 interacts and inhibits E2F1 transcriptional activity through an Rb-independent mechanism that involves recruitment of the SWI/SNF chromatin-remodeling complex proteins Brg1 and Brm.
    Product Specifications
    Catalog # Size Price
    TopBP1 AntibodyReactivity: Human, Mouse
    Applications: WB, IP, PLA
    Immunogen: Between 1400 and C-term
    A300-111A100 µl (1 mg/ml) $339Add to Cart
    A300-111A-M100 µl (10 blots) $229Add to Cart
    A300-111A-T20 µl (2 blots) $50Add to Cart

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