TReP-132/TRERF1 Antibody

The transcriptional regulating protein of 132 kDa (TReP-132/TRERF1) was identified as a transcription factor that interacts with and activates the promoter of the CYP11A1 gene, a gene that encodes cytochrome P450 side chain cleavage (P450scc) and catalyzes the first step in steroidgenesis. TRep-132 can function as a nuclear receptor co-activator and has been shown to interact with Sp1 and the progesterone receptor (PR) to suppress growth via activation of the gene promoters of the cyclin-dependent kinase inhibitors, p21 and p27.

Alternative names for TReP-132/TRERF1 Antibody include zinc finger transcription factor TReP-132 antibody, zinc-finger protein rapa antibody, breast cancer anti-estrogen resistance 2 antibody, BCAR2 antibody, RAPA antibody.