The transcriptional regulating protein of 132 kDa (TReP-132/TRERF1) was identified as a transcription factor that interacts with and activates the promoter of the CYP11A1 gene, a gene that encodes cytochrome P450 side chain cleavage (P450scc) and catalyzes the first step in steroidgenesis. TRep-132 can function as a nuclear receptor co-activator and has been shown to interact with Sp1 and the progesterone receptor (PR) to suppress growth via activation of the gene promoters of the cyclin-dependent kinase inhibitors, p21 and p27.
Alternative names for
TRERF1/TReP-132 Antibody include TRERF1 antibody,
Transcriptional-regulating factor 1 antibody,
Breast cancer anti-estrogen resistance 2 antibody,
Transcriptional-regulating protein 132 antibody,
Zinc finger protein rapa antibody,
Zinc finger transcription factor TReP-132 antibody,
transcriptional regulating factor 1 antibody,
transcriptional-regulating factor 1 antibody,
zinc finger protein rapa antibody,
transcriptional regulating protein 132 antibody,
transcriptional-regulating protein 132 antibody,
breast cancer anti-estrogen resistance 2 antibody,
zinc finger transcription factor TReP-132 antibody.