TOPORS (topoisomerase I-binding RS protein) was identified in a a yeast two-hybrid screen for proteins that bind the N-terminus of topoisomerase I. TOPORS contains a RING-type zinc-finger domain and an RS-rich region. TOPORS has been found to possess both ubiquitin and SUMO-1 E3 ligase activity. It can ubiquitinate and sumoylate p53 and may possibly function as a tumor suppressor. Defects in TOPORS are the cause of retinitis pigmentosa type 31.
Alternative names for
TOPORS Antibody include p53BP3 antibody,
E3 ubiquitin-protein ligase
SUMO1-protein E3 ligase
Topoisomerase I-binding RING finger protein antibody,
Topoisomerase I-binding arginine/serine-rich protein antibody,
Tumor suppressor p53-binding protein 3 antibody,
p53-binding protein 3 antibody,
topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase antibody,
tumor suppressor p53-binding protein 3 antibody,
topoisomerase I-binding RING finger protein antibody.