TDP2 (5’-Tyr-DNA phosphodiesterase 2) is also known as TTRAP (TRAF and TNF receptor-associated protein). TTRAP is a DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. It catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. TTRAP also hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. TTRAP may also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O95551].
Alternative names for
TDP2 Antibody include VPg unlinkase antibody,
VPg unlinkase antibody,
Tyrosyl-DNA phosphodiesterase 2 antibody,
5'-tyrosyl-DNA phosphodiesterase antibody,
ETS1-associated protein 2 antibody,
ETS1-associated protein II antibody,
TRAF and TNF receptor-associated protein antibody,
Tyrosyl-RNA phosphodiesterase antibody,
5'-Tyr-DNA phosphodiesterase antibody,
tyrosyl-DNA phosphodiesterase 2 antibody,
tyr-DNA phosphodiesterase 2 antibody,
tyrosyl-RNA phosphodiesterase antibody,
TRAF and TNF receptor associated protein antibody.