TDP1 Antibody

Tyrosyl-DNA phosphodiesterase 1 (TDP1) is an enzyme that participates in the repair of DNA strand breaks associated with topoisomerase 1 (Top1) complexes. TDP1 catalyzes the removal of Top1 from DNA via the hydrolysis of the phosphodiester bond between the tyrosine residue of Top1 and the 3’ phosphate of DNA. Removal of Top1 is then followed by DNA repair. TDP1 has been proposed to play more general roles in DNA damage repair independent of the Top1 complex. TDP1 has been shown to associate with DNA ligase IIIalpha, a component of the DNA single-stranded break repair (SSBR) machinery. It is also able to remove glycolate from 3’-phosphoglycolate termini of double-stranded breaks and a variety of other 3’- adducts. Defects in TDP1 are associated with spinocerebellar ataxia autosomal recessive with axonal neuropathy (SCAN1), a disease associated with peripheral axonal motor and sensory neuropathy and distal muscular atrophy.
    Product Specifications
    Catalog # Size Price
    TDP1 AntibodyReactivity: Human
    Applications: WB, IP, IHC-P, IF, PLA
    Immunogen: Between 1 and 50
    A301-618A100 µl (0.2 mg/ml) $339Add to Cart
    A301-618A-M100 µl (10 blots) $229Add to Cart
    A301-618A-T20 µl (2 blots) $50Add to Cart
    TDP1 AntibodyReactivity: Human
    Applications: IP
    Immunogen: Between 75 and 125
    A301-619A100 µl (1 mg/ml) $339Add to Cart
    A301-619A-T10 µl (1 mg/ml) $50Add to Cart
    TDP1 IHC AntibodyApplications: IHC-P, IF
    Reactivity: Human
    Immunogen: Between 1 and 50
    IHC-00322100 µl (50 slides) $360Add to Cart
    Applications: WB, IP, IHC-P, IF, PLA
    Reactivity: Human
    Includes: 1 each of A301-618A and A301-619A
    A310-574A1 Pack $472Add to Cart

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