TBLR1 is a six WD-40 repeat protein with high sequence homology to TBL1 (transducin beta-like protein 1) and is part of the SMRT (silencing mediator of retinoid and thyroid hormone receptors) and N-CoR (nuclear receptor corepressor) complexes that interact with nuclear receptors and repress transcription. Biochemical characterization of SMRT and N-CoR complexes demonstrate that SMRT and N-CoR are present in complexes that include HDAC3 (histone deacetylase 3), TBL1, and TBLR1. Association with HDAC3 indicates that these complexes may repress transcription through histone deacetylation and chromatin remodeling.
Alternative names for
TBLR1 Antibody include TBL1XR1 antibody,
F-box-like/WD repeat-containing protein TBL1XR1 antibody,
Nuclear receptor corepressor/HDAC3 complex subunit
TBL1-related protein 1 antibody,
Transducin beta-like 1X-related protein 1 antibody,
transducinbeta)-like 1 X-linked receptor 1 antibody,
transducin beta-like 1X-related protein 1 antibody,
nuclear receptor co-repressor/HDAC3 complex subunit antibody,
nuclear receptor corepressor/HDAC3 complex subunit TBLR1 antibody.