TAK1 Antibody

TAK1 (TGF-beta activated kinase 1) is also called mitogen-activated protein kinase kinase kinase 7 (MAP3K7). TAK1 is a serine/threonine protein kinase that mediates signals transduced by proinflammatory cytokines such as TGF-beta, tumor necrosis factor (TNF), interleukin-1 (IL-1) and wnt family ligands. TAK1 transduces signals by stimulating a MAPK pathway that ultimately stimulates JNK (c-terminal jun kinase) and p38 MAPKs. TAK1 is also an activator of the Ikappa B kinase that leads to the activation of NFkappa-B.
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