TAB182 Antibody

TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen in search of tankyrase 1-interacting proteins. Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor). Ribosylation of TRF1 has been shown to result in the inhibition of TRF1 binding and an induction of telomere elongation. TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain. This finding suggests that TAB182 may act as a scaffold to mediate higher order protein complex formation at telomeres. TAB182 has also been suggested to serve a role in the cytoplasm as it has been found to localize to the cytoplasmic cortical actin network.
    Product Specifications
    Catalog # Size Price
    TAB182 AntibodyReactivity: Human
    Applications: WB, IP
    Immunogen: Between 200 and 250
    A301-437A100 µl (0.2 mg/ml) $339Add to Cart
    A301-437A-M100 µl (10 blots) $229Add to Cart
    A301-437A-T20 µl (2 blots) $50Add to Cart
    TAB182 AntibodyReactivity: Human
    Applications: WB, IP
    Immunogen: Between 350 and 400
    A301-438A100 µl (0.2 mg/ml) $339Add to Cart
    A301-438A-M100 µl (10 blots) $229Add to Cart
    A301-438A-T20 µl (2 blots) $50Add to Cart
    TAB182 AntibodyReactivity: Human
    Applications: WB, IP
    Immunogen: Between 1679 and 1729
    A301-439A100 µl (0.2 mg/ml) $339Add to Cart
    A301-439A-M100 µl (10 blots) $229Add to Cart
    A301-439A-T20 µl (2 blots) $50Add to Cart

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