Synoviolin Antibody

The E3 ubiquitin-protein ligase synoviolin is also known as human HRD1. The original HRD1 (HMG-CoA reductase degradation) gene was identified as a mutant gene in yeast deficient for the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR). Homology between the human and yeast gene is limited to the N-terminal domain of the proteins, and human HRD1/Synoviolin does not appear to be involved in the degradation of mammalian HMGR. Synoviolin is involved in endoplasmic reticulum (ER)-associated degradation. It removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins.
    Product/Catalog #SpecificationsPrice
    Synoviolin Antibody
    A302-945A
    Reactivity: Human
    Applications: IP
    $314.00
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    Synoviolin Antibody
    A302-946A
    Reactivity: Human, Mouse
    Applications: WB, IP
    $314.00
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    Synoviolin Antibody AbVantage™ Pack
    A311-092A
    Applications: WB, IP
    Reactivity: Human, Mouse
    Quantity: 1 each of A302-945A and A302-946A
    $437.00
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