Synoviolin Antibody

The E3 ubiquitin-protein ligase synoviolin is also known as human HRD1. The original HRD1 (HMG-CoA reductase degradation) gene was identified as a mutant gene in yeast deficient for the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR). Homology between the human and yeast gene is limited to the N-terminal domain of the proteins, and human HRD1/Synoviolin does not appear to be involved in the degradation of mammalian HMGR. Synoviolin is involved in endoplasmic reticulum (ER)-associated degradation. It removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins.
    Product Specifications
    Catalog # Size Price
    Synoviolin AntibodyReactivity: Human
    Applications: IP
    Immunogen: Between 550 and 600
    A302-945A100 µl (1 mg/ml) $339Add to Cart
    A302-945A-T10 µl (1 mg/ml) $50Add to Cart
    Synoviolin AntibodyReactivity: Human, Mouse
    Applications: WB, IP
    Immunogen: Between 567 and 617
    A302-946A100 µl (0.2 mg/ml) $339Add to Cart
    A302-946A-M100 µl (10 blots) $229Add to Cart
    A302-946A-T20 µl (2 blots) $50Add to Cart
    Applications: WB, IP
    Reactivity: Human, Mouse
    Includes: 1 each of A302-945A and A302-946A
    A311-092A1 Pack $472Add to Cart

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