Spt16 Antibody

Spt16 is a Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is composed of two subunits: SSRP1 and Spt16. It is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, and then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y5B9].
    Product Specifications
    Catalog # Size Price
    Spt16 AntibodyReactivity: Human
    Applications: WB
    Immunogen: Between 997 and 1047
    A302-492A100 µl (1 mg/ml) $339Add to Cart
    A302-492A-M100 µl (10 blots) $229Add to Cart
    A302-492A-T20 µl (2 blots) $50Add to Cart

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