Sin1 Antibody

Stress-activated map kinase-interacting protein 1 (Sin1) is highly similar to the yeast stress- activated protein kinase SIN1. Sin1 is an essential mTORC2 subunit that is required to act as the PDK2 that phosphorylates Akt/PKB at Ser 473. Sin1 has been implicated as a scaffolding protein. Sin1 is required for rictor binding in the mTORC2 complex. Sin1 has also been shown to be important to the SAPK (stress-activated kinase) signaling pathway and in the nucleus may act as a scaffold between ATF-2 and p38 to facilitate p38-induced phosphorylation of ATF-2. Sin1 is also found to form a complex with c-Jun N-terminal kinase (JNK) and may similarly function as a scaffolding protein in JNK signaling.
    Product Specifications
    Catalog # Size Price
    Sin1 AntibodyReactivity: Human, Mouse
    Applications: WB, IP, IHC-P, IF, PLA
    Immunogen: Between 470 and C-term
    A300-910A100 µl (1 mg/ml) $339Add to Cart
    A300-910A-M100 µl (10 blots) $229Add to Cart
    A300-910A-T20 µl (2 blots) $50Add to Cart
    Reactivity: Human, Mouse
    Applications: IP
    Immunogen: Between 470 and C-term
    S300-910100 µg $356Add to Cart
    Sin1 IHC AntibodyApplications: IHC-P, IF
    Reactivity: Human, Mouse
    Immunogen: Between 470 and C-term
    IHC-00183100 µl (50 slides) $360Add to Cart

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