PTPN11/Shp2 is a src-homology 2-containing protein-tyrosine phosphatase (PTP). PTPN11/Shp2 is a non-receptor phosphatase that mediates a variety of cytokine, growth factor, and hormone signals. Signal transduction by PTPN11/Shp2 is achieved via the activation of the Ras/mitogen-activated protein kinase pathway. Heterogenous gain of function mutations in PTPN11/Shp2 are associated with juvenile myelomonocytic leukemia (JMML) and Noonan syndrome, a disorder characterized by short stature, facial dysmorphology, and congenital heart defects.
Alternative names for
Shp2/PTPN11 Antibody include tyrosine-protein phosphatase non-receptor type 11 antibody, protein-tyrosine phosphatase 2C antibody, PTP-2C antibody, PTP2C antibody, PTP-1D antibody, CFC antibody, NS1 antibody, SH-PTP3 antibody, SH-PTP2 antibody.