STUB1/CHIP is an E3 ubiquitin ligase and co-chaperone of heat-shock protein 70 (Hsp70). STUB1/CHIP interacts with Hsp70 to monitor protein folding and direct misfolded proteins for proteasomal degradation. It has been found to also associate with Hsp90 to remove phosphorylated protein tau, a protein that accumulates in the brains of Alzheimers and Down’s syndrome patients. STUB1/CHIP has been reported to also have intrinsic chaperone activity and recognize non-native proteins in response to heat stress. In this way, STUB1/CHIP has been shown to be a direct chaperone for p53.
Alternative names for
STUB1/CHIP Antibody include Antigen NY-CO-7 antibody,
antigen NY-CO-7 antibody,
E3 ubiquitin-protein ligase CHIP antibody,
CLL-associated antigen KW-8 antibody,
Carboxy terminus of Hsp70-interacting protein antibody,
STIP1 homology and U box-containing protein 1 antibody,
STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase antibody,
serologically defined colon cancer antigen 7 antibody,
carboxy terminus of Hsp70-interacting protein antibody,
heat shock protein A binding protein 2c-terminal) antibody.