SMG7 plays a role in the dephosphorylation of UPF1, an RNA-dependent ATPase and helicase critical to nonsense-mediated mRNA decay (NMD). It is a homolog of the C. elegans NMD factor Smg7 (suppressor with morphogenetic effect on genitalia protein 7). SMG7 functions as an adaptor to target protein phosphatase 2A to UPF1 for dephosphorylation of UPF1.
Alternative names for
SMG7 Antibody include EST1C antibody, SGA56M antibody, C1orf16 antibody, FLJ23717 antibody, KIAA0250 antibody.