SMC (Structural maintenance of chromosomes) proteins are part of the cohesin and condensin multisubunit complexes that play a critical role in chromosome organization, segregation, gene regulation, and DNA repair. The core condensin complex includes a heterodimer of SMC2 and SMC4 that functions to create positively supercoiled loops for chromatin condensation and metaphase chromatid shaping. A function for condensin in the DNA damage checkpoint response and gene repression has also been suggested.
Alternative names for
SMC4 Antibody include chromosome-associated polypeptide C antibody, hCAP-C antibody, XXAP-C homolog antibody, CAPC antibody, SMC4L1 antibody.