SMARCD2/BAF60b Antibody

The SMARCs (SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin), and BAFs (BRG1-associated factors), have been identified as components of the mammalian SWI/SNF-like chromatin-remodeling protein complexes. These multi-protein complexes are proposed to function as ATP-driven motors that translocate along DNA and destabilize nucleosomal structures to facilitate transcription factor binding. SMARCD2/BAF60B was isolated from a cDNA library in a search for proteins similar to mouse BAF60A which was identified as the paralog of the S. cerevisiae SWI/SNF component, SWP73.
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