Sharpin (Shank-associated RH domain-interacting protein) is a component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H0F6].
Alternative names for
SHARPIN Antibody include
Shank-associated RH domain-interacting protein antibody,
Shank-interacting protein-like 1 antibody,
SHANK-associated RH domain interactor antibody,
shank-interacting protein-like 1 antibody,
shank-associated RH domain-interacting protein antibody.