Regulatory factor X- associated protein (RFXAP) is a 36kDa subunit of the regulatory factor X (RFX) heteromeric complex that activates the transcription of major histocompatibility class II (MHC-II) genes by binding MHC-II promoter elements. The RFX complex consists of RFXAP, RFXANK, and RFX5. Mutations in the genes of this complex result in a lack of MHCII transcription and lead to the severe combined immunodeficiency disease, Bare Lymphocyte Syndrome (BLS).
Alternative names for
RFXAP Antibody include
Regulatory factor X-associated protein antibody,
RFX DNA-binding complex 36 kDa subunit antibody,
regulatory factor X-associated protein antibody,
RFX-associated protein antibody.