The agouti (a) locus includes the mouse agouti gene that regulates coat color in mice by controlling the relative amount and distribution of yellow and black pigment in the coat hairs. A mutation in the agouti locus, lethal yellow (Ay), results in an all-yellow coat color along with a number of dominant pleiotropic effects such as obesity, diabetes, tumor susceptibility, and embryonic lethality in homozygotes. Molecular analysis of the Ay transcript revealed that the Ay transcript includes the coding region of the a gene but also included novel sequence. The novel sequence was found to originate from a 5’-noncoding exon of a gene that was named Raly, because it had the potential to encode an hnRNP protein that is associated with lethal yellow.
Alternative names for
RALY Antibody include autoantigen p542 antibody, HNRNPCL2 antibody, P452 antibody.