ZAP-70 (zeta associated protein 70) is a tyrosine kinase of the Src family of tyrosine kinases. It was initially identified as a partner of the zeta chain of the CD3 complex associated to the T-cell receptor on T-lymphocytes. ZAP-70 shares homology with spleen-tyrosine kinase (Syk), a kinase involved in B-cell activation. Both ZAP-70 and Syk have been shown to be crucial to B- and T-lymphocyte development. In T-cells ZAP-70 functions to transduce the signaling cascade activated by T-cell receptor engagement and activation.
Alternative names for
Phospho ZAP70 (Y319) Antibody include
Tyrosine-protein kinase ZAP-70 antibody,
70 kDa zeta-chain associated protein antibody,
Syk-related tyrosine kinase antibody,
zeta-chainTCR) associated protein kinase 70kDa antibody,
tyrosine-protein kinase ZAP-70 antibody,
syk-related tyrosine kinase antibody,
70 kDa zeta-associated protein antibody,
zeta-chain associated protein kinase, 70kD antibody.