BRCA1 was identified as a gene with germline mutations that predisposes women to breast and ovarian cancer. The BRCA1 tumor suppressor is a large protein that has been demonstrated to interact with a multitude of proteins involved in the DNA damage response and cell cycle checkpoints to maintain genomic integrity. BRCA1 functions by regulating the activities of its interacting proteins which mediate processes such as gene transcription, gene repression, protein phosphorylation, and ubiquitination.
Alternative names for
Phospho BRCA1 (S1423) Antibody include breast cancer type 1 susceptibility protein antibody, RING finger protein 53 antibody, RNF53 antibody, IRIS antibody, PSCP antibody, BRCAI antibody, BRCC1 antibody.