Parafibromin Antibody

Parafibromin, also known as HRPT2 (hyperparathyroidism 2 protein), has been identified as a tumor suppressor that is associated with hyperparathyroidism-jaw tumor syndrome, an autosomal dominant disease characterized by hyperparathyroidism due to parathyroid tumors and ossifying fibromas of the mandible and maxilla. Parafibromin is a component of the PAF1 complex that associates with RNA polymerase II and plays a role in mRNA 3’-end processing and transcription elongation. Parafibromin has been demonstrated to function as an inhibitor of the cell cycle.

Alternative names for Parafibromin Antibody include cell division cycle protein 73 homolog antibody, CDC73 antibody, HPT-JT antibody, C1orf28 antibody, FLJ23316 antibody, HRPT2 antibody.