PUS1 Antibody

Pus1 (pseudouridylate synthase 1) is an enzyme that converts uridine to pseudouridine in non-coding RNA substrates. Pus1 modifies uridines at specific positions in a subset of tRNAs. Pseudouridylation is known to affect the structure of tRNAs and stabilize base-stacking and base-pairing in the anticodon loop. Pus1 activity is important for proper folding and function of tRNAs. Pus1 has also been shown to pseudouridylate SRA (steroid receptor RNA activator) and function as a coactivator. Defects in pseudouridylation are associated with the human disease, MLASA (myopathy with lactic acidosis and sideroblastic anemia), an autosomal recessive oxidative phosphorylataion disorder specific to skeletal muscle and bone marrow.
    Product Specifications
    Catalog # Size Price
    PUS1 AntibodyReactivity: Human
    Applications: WB, IP, IHC-P, IF
    Immunogen: Between 377 and 427
    A301-651A100 µl (0.2 mg/ml) $339Add to Cart
    A301-651A-M100 µl (10 blots) $229Add to Cart
    A301-651A-T20 µl (2 blots) $50Add to Cart
    PUS1 IHC AntibodyApplications: IHC-P, IF
    Reactivity: Human
    Immunogen: Between 377 and 427
    IHC-00347100 µl (50+ slides) $360Add to Cart
    IHC-00347-T10 µl (5+ slides) $50Add to Cart

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