PTPN11/Shp2 Antibody

PTPN11/Shp2 is a src-homology 2-containing protein-tyrosine phosphatase (PTP). PTPN11/Shp2 is a non-receptor phosphatase that mediates a variety of cytokine, growth factor, and hormone signals. Signal transduction by PTPN11/Shp2 is achieved via the activation of the Ras/mitogen-activated protein kinase pathway. Heterogenous gain of function mutations in PTPN11/Shp2 are associated with juvenile myelomonocytic leukemia (JMML) and Noonan syndrome, a disorder characterized by short stature, facial dysmorphology, and congenital heart defects.
    Product Specifications
    Catalog # Size Price
    PTPN11/Shp2 AntibodyReactivity: Human, Mouse
    Applications: WB, IP
    Immunogen: Between 543 and 593
    A301-544A100 µl (1 mg/ml) $339Add to Cart
    A301-544A-M100 µl (10 blots) $229Add to Cart
    A301-544A-T20 µl (2 blots) $50Add to Cart

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