PRCC Antibody

In a subset of papillary renal cell carcinomas, a t(X;1)(p11;q21) chromosome translocation has been repeatedly reported and is thought to be the cause of the cancer. As a result of the translocation, the transcription factor TFE3 on the X chromosome becomes fused to the PRCC (papillary renal cell carcinoma translocation-associated) gene on chromosome 1. The fused gene results in the fusion of N-terminal proline-rich region of the protein encoded by this gene to the entire TFE3 protein. This protein has been shown to interact with the mitotic checkpoint protein MAD2B, which suggests that the dominant-negative effect of the fusion protein with TFE3 may lead to a mitotic checkpoint defect [taken from NCBI GeneID:5546].
    Product Specifications
    Catalog # Size Price
    PRCC AntibodyReactivity: Human
    Applications: IP, IHC-P, IF
    Immunogen: Between 125 and 175
    A302-339A100 µl (1 mg/ml) $339Add to Cart
    A302-339A-T10 µl (1 mg/ml) $50Add to Cart
    PRCC AntibodyReactivity: Human, Mouse
    Applications: WB, IP
    Immunogen: Between 425 and 475
    A302-340A100 µl (1 mg/ml) $339Add to Cart
    A302-340A-M100 µl (10 blots) $229Add to Cart
    A302-340A-T20 µl (2 blots) $50Add to Cart

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