PP2A is a major serine/threonine phosphatase that is implicated in the negative control of cell cycle progression. It is a trimeric holoenzyme that is comprised of a catalytic, structural, and regulatory subunit. PPP2R2B is a regulatory subunit of PP2A. The regulatory subunits of PP2A are grouped into 3 families: B/PR55, B’/PR61, and B’’/PR72. PPP2R2B encodes a beta isoform of the B/PR55 subunit family. PPP2R2B is brain specific. An expansion of a CAG repeat in the 5’region of PP2R2B is associated with spinocerebellar ataxia type 12 (SCA12), an autosomal dominant neurodegenerative disorder.
Alternative names for
PPP2R2B Antibody include serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform antibody, PP2A subunit B B55-beta isoform antibody, PP2A subunit B antibody, PR55-beta isoform antibody, PP2A subunit B R2-beta isoform antibody, PR52B antibody, SCA12 antibody, MGC24888 antibody, PR55-BETA antibody, PP2A antibody, PR55B antibody, PR2AB-BETA antibody, PR2AB55-BETA antibody, PR2APR55-BETA antibody.