PKM2 Antibody

Pyruvate Kinase M2 (PKM2) is a glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. PKM2 also stimulates POU5F1-mediated transcriptional activation, and plays a general role in caspase independent cell death of tumor cells [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P14618].

Alternative names for PKM2 Antibody include pyruvate kinase isozymes M1/M2 antibody, cytosolic thyroid hormone-binding protein antibody, CTHBP antibody, opa-interacting protein 3 antibody, OIP-3 antibody, pyruvate kinase 2/3 antibody, pyruvate kinase muscle isozyme antibody, thyroid hormone binding protein 1 antibody, THBP1 antibody, tumore M2-PK antibody, p58 antibody, OIP3 antibody, PK3 antibody, PKM antibody, TCB antibody.