PHLPP (PH domain leucine-rich repeat-containing protein phosphatase) is responsible for the dephosphorylation and subsequent inactivation of Akt. Akt is a signaling protein critical to the balance of cell survival and apoptosis. Dephosphorylation of Akt by PHLPP has been demonstrated to trigger apoptosis and suppress tumor cell growth. PHLPP functions similarly to its relative PHLPPL, also known as PHLPPL2. Recent studies show that PHLPP and PHLPPL selectively terminate Akt-signaling by targeting specific Akt isoforms.
Alternative names for
PHLPP Antibody include hSCOP antibody,
PH domain leucine-rich repeat-containing protein phosphatase 1 antibody,
Pleckstrin homology domain-containing family E member 1 antibody,
Suprachiasmatic nucleus circadian oscillatory protein antibody,
PH domain-containing family E member 1 antibody,
PH domain and leucine rich repeat protein phosphatase 1 antibody,
SCN circadian oscillatory protein antibody,
suprachiasmatic nucleus circadian oscillatory protein antibody,
pleckstrin homology domain containing, family Ewith leucine rich repeats) member 1 antibody.