PHD4 is one of 4 PHD (PHD1-4) enzymes that function as oxygen sensors and are responsible for the post-translational modification of HIF-1alpha, a component of a transcriptional complex involved in oxygen homeostasis. During normoxic levels, PHDs catalyze the hydroxylation of prolyl residues on HIF-1alpha and target it for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. The PHD isoforms appear to function in a non-redundant manner and may differ in their expression patterns and their catalytic selectivity.
Alternative names for
PHD4 Antibody include PHD4 antibody, PH4 antibody, PHD4 antibody, Prolyl hydroxylase domain-containing 4 antibody, HIFPH4 antibody, HIF prolyl 4-hydroxylase antibody, FLJ20262 antibody.