PHD2 Antibody

PHD2 is one of 4 PHD (PHD1-4) enzymes that function as oxygen sensors and are responsible for the post-translational modification of HIF-1alpha, a component of a transcriptional complex involved in oxygen homeostasis. During normoxic levels, PHDs catalyze the hydroxylation of prolyl residues on HIF-1alpha and target it for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. The PHD isoforms appear to function in a non-redundant manner and may differ in their expression patterns and their catalytic selectivity.

Alternative names for PHD2 Antibody include PHD2 antibody, PH2 antibody, Prolyl hydroxylase domain containing protein 2 antibody, HIF2PH2 antibody, HIF-Prolyl hydroxylase 2 antibody, EGLN1 antibody, egl nine homolog 1 antibody, C1orf12 antibody.