PDK1 (3-phosphoinositide-dependent kinase-1) is a serine/threonine kinase that contains a PH domain for binding of phosphatidylinositols (PtdIns). PDK1 phosphorylates PKB/AKT in response to agonist stimulation of phosphoinositide 3-kinases (PI3Ks). Stimulation of PI3Ks generates specific inositol lipids that are important for activation of PDK1. PDK1 may also be responsible for phosphorylating PKA, PKC-zeta, RPS6KA1, and RPS6KB1.
Alternative names for
PDK1 Antibody include PDPK1 antibody,
3-phosphoinositide-dependent protein kinase 1 antibody,
3-phosphoinositide dependent protein kinase-1 antibody,
PkB kinase like gene 1 antibody.