PARN Antibody

Poly(A)-specific ribonuclease (PARN) is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. PARN prefers poly(A) as the substrate, hence, it efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. PARN is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons [taken from NCBI Entrez Gene (Gene ID: 5073)].
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