NUPL Antibody

NUPL or hRIP (human Rev interacting protein) was originally identified in a yeast two-hybrid screen for proteins that interact with the Rev protein of the human immunodeficiency virus type 1 (HIV-1). Structurally, hRIP contains an ARFGAP (ARF GTPase-activating protein) domain. hRIP was found to have homology with nucleoporins; thus it is also referred to as nucleoporin-like protein (NUPL) RIP. hRIP is essential to HIV-1 replication but not for cell viability, and it appears to be important for the export of HIV-1 RNA from the perinuclear region to the cytoplasm.
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