N-terminal RCC1 methyltransferase (NRMT) is an alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. NRMT specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. NRMT is responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET and is required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9BV86].
Alternative names for
NRMT Antibody include alpha N-terminal protein methyltransferase 1A antibody, methyltransferase-like protein 11A antibody, X-Pro-Lys N-terminal protein methyltransferase 1A antibody, NTM1A antibody, METTL11A antibody, C9orf32 antibody.