NP95/UHRF1 Antibody

NP95/UHRF1 was originally identified as ICBP90 (inverted CCAAT box-binding protein of 90 kDa) in a one-hybrid screen for proteins that bind the topoisomerase IIalpha gene promoter. NP95/UHRF1 is a heterochromatin binding protein that directly interacts with histones and has proposed roles in the DNA damage response, heterochromatin formation, and cell replication. Structurally, NP95/UHRF1 contains an ubiquitin-like domain (NIRF_N), a plant homeodomain (PHD), a SRA domain, and a RING domain. The RING domain imparts ubiquitin E3 ligase activity that is histone-specific. This E3 ligase activity is proposed to be important to tumor growth. NP95/UHRF1 expression begins in the G1/S phase and continues through mitosis. It has been shown to be required for entry from G1/G0 as well as the G1/S transition in some cell types. NP95/UHRF1 has been found to be part of the pericentric heterochromatin duplication body (pHDB) and involved in the replication and formation of heterochromatin.
    Product Specifications
    Catalog # Size Price
    NP95/UHRF1 AntibodyReactivity: Human
    Applications: WB, IP, IHC-P, IF
    Immunogen: Between 275 and 325
    A301-470A100 µl (0.2 mg/ml) $339Add to Cart
    A301-470A-M100 µl (10 blots) $229Add to Cart
    A301-470A-T20 µl (2 blots) $50Add to Cart
    NP95/UHRF1 IHC AntibodyApplications: IHC-P, IF
    Reactivity: Human
    Immunogen: Between 275 and 325
    IHC-00554100 µl (50+ slides) $360Add to Cart
    IHC-00554-T10 µl (5+ slides) $50Add to Cart

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