NONO Antibody

Non-POU-domain-containing octamer binding protein (NONO) is a member of the DBHS (drosophila behavior, human splicing) domain-containing family and is an RNA- and DNA- binding protein. NONO and other DBHS domain-containing proteins are multifunctional and are reported to be involved in transcriptional regulation, mRNA processing, and DNA non-homologous end joining (NHEJ). NONO functions as a coregulator of the androgen receptor (AR) and also regulates cAMP transcriptional activity by interacting with gene promoter elements. NONO is also involved in pre-mRNA splicing through an interaction with U5 snRNA and can stimulate DNA nonhomologous end joining (NHEJ) through the interaction with ku70/G22p and ku80/XRCC5 dimers.

Alternative names for NONO Antibody include 54 kDa nuclear RNA- and DNA-binding protein antibody, p54 (nrb) antibody, 55 kDa nuclear protein antibody, NMT55 antibody, DNA-binding p52/p100 complex antibody, NRB54 antibody, P54 antibody, P54NRB antibody.