NIPA Antibody

Nuclear-interacting partner of ALK (NIPA) is an essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. NIPA may have an antiapoptotic role in NPM-ALK-mediated signaling events [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q86WB0].
    Product Specifications
    Catalog # Size Price
    NIPA AntibodyReactivity: Human
    Applications: IP
    Immunogen: Between 1 and 50
    A302-941A100 µl (1 mg/ml) $339Add to Cart
    A302-941A-T10 µl (1 mg/ml) $50Add to Cart
    NIPA AntibodyReactivity: Human
    Applications: WB, IP
    Immunogen: Between 300 and 350
    A302-942A100 µl (0.2 mg/ml) $339Add to Cart
    Applications: WB, IP
    Reactivity: Human
    Includes: 1 each of A302-941A and A302-942A
    A311-090A1 Pack $472Add to Cart

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