NIPA Antibody

Nuclear-interacting partner of ALK (NIPA) is an essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. NIPA may have an antiapoptotic role in NPM-ALK-mediated signaling events [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q86WB0].
    Product/Catalog #SpecificationsPrice
    NIPA Antibody
    A302-941A
    Reactivity: Human
    Applications: IP
    $314.00
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    NIPA Antibody
    A302-942A
    Reactivity: Human
    Applications: WB, IP
    $314.00
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    Data Sheet
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    NIPA Antibody AbVantage™ Pack
    A311-090A
    Applications: WB, IP
    Reactivity: Human
    Quantity: 1 each of A302-941A and A302-942A
    $437.00
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    Data Sheet
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