Nuclear-interacting partner of ALK (NIPA) is an essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. NIPA may have an antiapoptotic role in NPM-ALK-mediated signaling events [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q86WB0].
Alternative names for
NIPA Antibody include h
Nuclear-interacting partner of ALK antibody,
Nuclear-interacting partner of anaplastic lymphoma kinase antibody,
Zinc finger C3HC-type protein 1 antibody,
zinc finger, C3HC-type containing 1 antibody,
nuclear-interacting partner of ALK antibody,
zinc finger, C3HC type 1 antibody,
zinc finger C3HC-type protein 1 antibody,
nuclear interaction partner of ALK antibody,
hematopoietic stem/progenitor cell protein 216 antibody,
nuclear-interacting partner of anaplastic lymphoma kinase antibody,
nuclear interacting partner of anaplastic lymphoma kinaseALK) antibody.