Inactivating mutations in NF1 (neurofibromin 1) result in neurofibromatosis type I (NF1) which is characterized by Schwann cell neurofibromas, café-au-lait spots, and benign lesions of the iris. At the cellular level, NF1 functions as a negative regulator of Ras activity. Loss of NF1 leads to increased levels of active Ras-GTP which is important for the formation and maintenance of Schwann cell tumors.
Alternative names for
NF1 Antibody include Neurofibromin antibody,
neurofibromin 1 antibody,
Neurofibromatosis-related protein NF-1 antibody,
neurofibromatosis-related protein NF-1 antibody.