Mel18 is a transcriptional repressor and binds specifically to the DNA sequence 5'-GACTNGACT-3'. Mel-18 is a component of a polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. Mel-18 has tumor suppressor activity. Mel-18 plays a role in control of cell proliferation and/or neural cell development, and also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P35227].
Alternative names for
Mel-18 Antibody include polycomb group ring finger 2 antibody, PCGF2 antibody, RING finger protein 110 antibody, RNF110 antibody, zinc finger protein 144 antibody, RNF110 antibody, ZNF144 antibody.