MSK1 is a serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). MSK1 Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. MSK1 also phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O75582].
Alternative names for
MSK1 Antibody include ribosomal protein S6 kinase alpha-5 antibody, S6K-alpha-5 antibody, nuclear mitogen- and stress-activated protein kinase 1 antibody, 90kDa ribosomal proein S6 kinase 5 antibody, RSK-like protein kinase antibody, RPS6KA5 antibody, RLPK antibody, MSPK1 antibody.