Defects in the Midline-1 (MID1) gene are the cause of Opitz syndrome, an X-linked recessive disorder characterized by developmental defects. MID1 is a microtubule-associated protein (MAP) with E3 ubiquitin ligase activity. MID1 has been shown to target protein phosphatases 2A (PP2Ac) on microtubules for degradation. MID1 association with PP2A has been proposed to regulate microtubule stabilization for cellular processes such as cell division and migration.
Alternative names for
MID1 Antibody include midin antibody, midline1 RING finger protein antibody, RING finger protein 59 antibody, tripartite motif-containing protein 18 antibody, RNF59 antibody, TRIM18 antibody, FXY antibody, XPRF antibody.