Defects in the Midline-1 (MID1) gene are the cause of Opitz syndrome, an X-linked recessive disorder characterized by developmental defects. MID1 is a microtubule-associated protein (MAP) with E3 ubiquitin ligase activity. MID1 has been shown to target protein phosphatases 2A (PP2Ac) on microtubules for degradation. MID1 association with PP2A has been proposed to regulate microtubule stabilization for cellular processes such as cell division and migration.
Alternative names for
MID1 Antibody include Midline-1 antibody,
Midline 1 RING finger protein antibody,
Putative transcription factor XPRF antibody,
RING finger protein 59 antibody,
Tripartite motif-containing protein 18 antibody,
midline 1Opitz/BBB syndrome) antibody,
midline 1 RING finger protein antibody,
tripartite motif protein TRIM18 antibody,
putative transcription factor XPRF antibody,
tripartite motif-containing protein 18 antibody,
zinc finger on X and Y, mouse, homolog of antibody.