MIB2/Skeletrophin is an actin-binding protein that bears two MIB/HERC2 domains, a ZZ-type zinc-finger domain, nine ankyrin repeats, and two RING-finger domains. The C-terminal RING domain has been found to have E3 ubiquitin ligase activity that mediates ubiquitination of the intracellular regions of the Notch receptor and its ligands to regulate Notch signaling. MIB2/Skeletrophin appears to be important to muscle development and may function as a suppressor of melanoma invasion.
Alternative names for
MIB2/Skeletrophin Antibody include Skeletrophin antibody,
E3 ubiquitin-protein ligase MIB2 antibody,
Mind bomb homolog 2 antibody,
Novel zinc finger protein antibody,
Putative NF-kappa-B-activating protein 002N antibody,
Zinc finger ZZ type with ankyrin repeat domain protein 1 antibody,
mindbomb E3 ubiquitin protein ligase 2 antibody,
mindbomb homolog 2 antibody,
mind bomb homolog 2 antibody,
novel zinc finger protein antibody,
putative NF-kappa-B-activating protein 002N antibody,
zinc finger, ZZ type with ankyrin repeat domain 1 antibody,
zinc finger ZZ type with ankyrin repeat domain protein 1 antibody.