MAP4K4/HGK Antibody

MAP4K4 is a serine/threonine kinase that signals upstream of the c-Jun N-terminal kinase (JNK) and is involved in cell motility. MAP4K4 appears to partially mediate TNF alpha signaling. In skeletal muscle TNF-alpha induces insulin resistance. TNF-alpha induced insulin resistance has been shown to be dependent on MAPK4K4 activity. Interestingly, TNF-alpha regulates MAP4K4 expression and can stimulate MAP4K4 gene expression via TNFR2 (TNFalpha receptor 2) and the c-Jun and ATF2 (activating transcription factor 2) transcription factors. MAP4K4 is highly expressed in most tumor cell lines, and the analysis of MAP4K4 mutants indicates that it may have an important role in cell transformation and invasiveness.
    Product Specifications
    Catalog # Size Price
    MAP4K4/HGK AntibodyReactivity: Human
    Applications: WB, IP, IHC-P, IF
    Immunogen: Between 550 and 600
    A301-502A100 µl (1 mg/ml) $339Add to Cart
    A301-502A-M100 µl (10 blots) $229Add to Cart
    A301-502A-T20 µl (2 blots) $50Add to Cart

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