MAML2 Antibody

There are 3 MAML (mastermind-like) proteins in mammals (MAML1-3). MAML2 is a critical coactivator for NOTCH signaling. MAML2 associates with NOTCH and CSL in a ternary complex and functions to activate transcription of HES and hairy-related basic helix-loop-helix transcription factors. MAML2 has been identified in a chromosomal rearrangement and fusion with MECT1 in mucoepidermoid carcinomas, secondary acute myeloid leukemia, hidradenomas, and myelodysplastic syndrome. MECT1 is a CREB regulator, and when fused with the transactivational domain of MAML2, imparts constitutive activation of CREB-dependent transcription that may promote oncogenesis.
    Product Specifications
    Catalog # Size Price
    MAML2 AntibodyReactivity: Human
    Applications: IP
    Immunogen: Between 250 and 300
    A300-681A100 µl (1 mg/ml) $339Add to Cart
    MAML2 AntibodyReactivity: Human, Mouse
    Applications: WB, IP, IHC-P, IF
    Immunogen: Between 1100 and C-term
    A300-682A100 µl (0.2 mg/ml) $339Add to Cart
    A300-682A-M100 µl (10 blots) $229Add to Cart
    A300-682A-T20 µl (2 blots) $50Add to Cart

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