Lissencephaly-1 protein (LIS-1) was identified as a gene associated with Miller-Dieker lissencephaly syndrome, an autosomal dominant disorder characterized by microcephaly along with anomalies of the kidney, heart, and gastrointestinal tract. LIS-1 is the non-catalytic alpha subunit of the intracellular isoform of platelet-activating factor acetylhydrolase. LIS-1 plays an important role in neuron migration during brain development and fibroblast migration during wound healing. Its role in migration is related to its function in regulating dynein-mediated microtubule sliding.
Alternative names for
LIS-1 Antibody include platelet-activating factor acetylhydrolase IB subunit alpha antibody, PAF-AH alpha antibody, PAFAH alpha antibody, PAFAH1B1 antibody, LIS1 antibody, MDCR antibody, MDS antibody, PAFAHA antibody.